Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiling of adipocyte precursor cells (AP) nonwounded and day 5 wound beds

ABSTRACT: APs were isolated from naïve skin and day 5wounds from dorsal skin wound beds of 7-9 weeks old using FACS. This experiment describes changes in AP gene expression associated with injury and subsequent tissue repair.

ORGANISM(S): Mus musculus

PROVIDER: GSE105788 | GEO | 2018/11/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profiling of myofibroblasts in young and aged day 5 wound beds

Project description:Mesenchymal cells were isolated from day 5 dorsal skin wound beds of 7-weeks old and >24-months old using FACS. This experiment describes multiple unique subsets of wound bed myofibrolbasts capable of contributing to tissue repair.

2018-11-06 | GSE105790 | GEO

Gene expression profiling of adipocyte precursor cells (AP) nonwounded and day 5 wound beds

Project description:Gene expression profiling of adipocyte precursor cells (AP) nonwounded and day 5 wound beds

| PRJNA415412 | ENA

Gene expression profiling of CD301b+ macrophages and F4/80 negative immune cells from day 5 mouse wound beds

Project description:Cells were isolated from day 5wounds from dorsal skin wound beds of 7-9 weeks old using FACS. This experiment describes the gene expression profile associated with different immune cell subsets during tissue repair.

2018-11-06 | GSE105789 | GEO

Gene expression profiling of skin adipocyte and adipocyte derived cells in mice 5 days after injury

Project description:Cells were isolated from day 5wounds from dorsal skin wound beds of 7-9 weeks old using FACS. This experiment describes the gene expression profile associated with mature adipocytes, adipocyte-derived cells and myofibroblasts during tissue repair.

2020-02-14 | GSE126514 | GEO

scRNA-Seq for mouse wounded and non-wounded samples

Project description:Lineage negative (CD45- & CD31-) cells were isolated from uninjured skin and day 5 dorsal skin wound beds of 7-week-old AdipoqCre; mT/mG mice using FACS. This experiment describes multiple subsets of wound bed myofibroblasts and identifies that Adipoq-traced cells contribute to the myofibroblast pool in wound beds.

2020-04-14 | GSE140512 | GEO

Chromatin accessibility analysis of adipose progenitors (AP).

Project description:We hypothesized that core transcriptional regulatory circuitries analysis could be used in conjunction with gene expression profiling data to nominate specific TFs for additional functional studies of AP cell state. To accomplish this analysis, we utilized the assay of transposase-accessible chromatin coupled to massively parallel sequencing (ATAC-seq) to identify putative enhancers in APs. The AP preparation involved adipose tissue digestion, and negative selection of the stromal vascular fraction (depletion of CD31+ endothelial cells and Lineage positive cells).

2018-08-22 | GSE118856 | GEO

Role of AP-2a/AP-2b transcription factors in the adult epidermis.

Project description:To investigate the effects of inactivation of the transcription factors AP-2a and/or AP-2b in the adult mouse skin.

2023-12-20 | GSE248372 | GEO

Molecular profiling of vascular beds in vivo by DISDIVO

Project description:We developed a new technique named as Differential Systemic Decellularization in vivo (DISDIVO) for the molecular profiling of vascular beds throughout the body. This method can by applied to murine models. Thus, the data provided here correspond to mice vascular beds obtained in vivo by DISDIVO.

2018-12-06 | PXD008794 | Pride

Adipose Precursor HO-1 prevents healthy visceral adipose tissue expansion during obesity[II]

Project description:Excessive accumulation of white adipose tissue (WAT) is a hallmark of obesity. The expansion of WAT in obesity involves proliferation and differentiation of adipose precursors (APs), however, the underlying molecular mechanisms remain unclear. Here, we identify Heme Oxygenase-1 (HO-1) as selectively being upregulated in the AP fraction of WAT, upon high-fat diet (HFD) feeding. Specific conditional deletion of HO-1 in APs of Hmox1fl/fl-Pdgfra Cre mice enhanced HFD-dependent visceral AP proliferation and differentiation, upstream of Cebpα and PPARγ. Opposite effects on human preadipocyte proliferation and differentiation in vitro were observed following HO-1 overexpression. Mechanistically, HO-1 acts upstream of AKT2 via ROS thresholding in mitochondria. Deletion of HO-1 in APs is sufficient to lower blood glucose, insulin and free fatty acid levels as well as liver steatosis during obesity, an effect not seen when HO-1 was conditionally deleted at later stages of adipogenesis using AdipoQ-Cre. Together, our data identify HO-1 as a diet-induced regulator limiting visceral adipose tissue hyperplasia during obesity.

2017-03-08 | GSE80147 | GEO

Adipose Precursor HO-1 prevents healthy visceral adipose tissue expansion during obesity [I]

2017-03-08 | GSE80146 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data