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MiRNA expression data from adult mouse Prefrontal Cortex following high fat diet exposure (8 weeks, starting on PND28)

ABSTRACT: High-fat diet (HFD) feeding during adolescence induces robust impairments in prefrontal-dependent cognition. Moreover, it also provokes multiple changes at the cellular and synaptic scales within the mPFC, suggesting that major transcriptional events are elicited by HFD during this maturational period. While it has been speculated that the nature of this transcriptional reprogramming may involve epigenetic effects, such as microRNA expression, this question to date remains unanswered. Here, we addressed this issue by performing unbiased genome-wide transcriptional profiling of miRNAs in the mouse mPFC following adolescent HFD. We performed unbiased genome-wide transcriptional profiling of miRNAs in the mouse mPFC following adolescent HFD

ORGANISM(S): Mus musculus synthetic construct

PROVIDER: GSE105794 | GEO | 2017/10/24

SECONDARY ACCESSION(S): PRJNA415430

REPOSITORIES: GEO

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Inhibition of BET proteins during adolescence affects prefrontal cortex development: relevance to schizophrenia

Project description:Background: The present study investigated a role of proteins from BET family (epigenetic readers) in schizophrenia-like abnormalities in MAM-E17 model of schizophrenia. Methods: An inhibitor of BET proteins, JQ1, was given during adolescence in postnatal days (P) 23-P30, and behavioral response (sensorimotor gating, recognition memory) and prefrontal cortex (mPFC) function (long-term potentiation (LTP), molecular and proteomic studies) were performed in adult males and females. Results: Deficits in sensorimotor gating and recognition memory were observed only in MAM-treated males. However, adolescent JQ1 treatment affected control, but MAM-treated groups in both sexes. Electrophysiological study showed an LTP impairment only in male MAM-treated animals, and JQ1 did not have any effect on LTP in the mPFC. In contrast, MAM did not affect immediate early gene expression (markers of neuronal and synaptic activity), but JQ1 altered them in both sexes. Proteomic study revealed alterations in MAM-treated groups only in males, while JQ1 affected both sexes. Conclusions: Prenatal MAM administration induced schizophrenia-like abnormalities only in males. In contrast, adolescent JQ1 treatment affected both sexes and induced behavioral changes in control groups, altered a markers of neuronal and synaptic activity and proteomic landscape in the mPFC of both groups (VEH- and MAM-treated). Thus, adolescent inhibition of BET family might change neuroplasticity in the mPFC.

2021-09-07 | PXD027050 | Pride

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microRNA expression data from medial prefrontal cortex (mPFC) of Rat

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Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans [RNA-seq]

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Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans [RRBS-seq]

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