Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia

ABSTRACT: Acute myeloid leukemia (AML) is an aggressive malignancy that can only be cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related morbidity and mortality. Disease-stabilizing therapy is then the only possible strategy, one alternative being treatment based on all-trans retinoic acid (ATRA) combined with the histone deacetylase inhibitor valproic acid and possibly low-toxicity conventional chemotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106096 | GEO | 2017/10/25

SECONDARY ACCESSION(S): PRJNA415597

REPOSITORIES: GEO