Transfer RNA Genes Affect Chromosome Architecture and Function [ChIP-seq]

ABSTRACT: In this study, we investigated the role of tranfer RNA genes (tDNAs) in genome organization and nuclear function by generating a chromosome lacking all its tDNAs. Our analyses of this tDNA-less chromosome show that loss of these genes affects nucleosome postioning, SMC protein binding, centromere clustering, long range chromosome folding and epigenetic silencing.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE106249 | GEO | 2019/03/05

REPOSITORIES: GEO