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RNA sequencing analysis of PINCH mutant sciatic nerves

ABSTRACT: During peripheral nervous system (PNS) development, Schwann cells (SC) depend on interactions between extracellular matrix proteins, integrins and growth factor signal transduction pathways for survival, sorting and wrapping of axon segments to form myelin. Together with integrin-linked-kinase and parvins, PINCH (Particularly-interesting-new-cystidin-hystidin-rich protein) forms a heterotrimeric complex referred to as the IPP complex, which functions as a signaling hub connecting integrins with various signaling pathways. Using SC-specific conditional gene targeting in mice, gene expression profiling by RNAseq, and other methodologies, we demonstrate distinct functional roles for PINCH1 and PINCH2 in SC.

ORGANISM(S): Mus musculus

PROVIDER: GSE106413 | GEO | 2017/12/31

SECONDARY ACCESSION(S): PRJNA416793

REPOSITORIES: GEO

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