Spontaneous Tfh cells in lupus mice vs B6/J

ABSTRACT: Autoimmune T follicular helper (Tfh) cells have different properties from B6/J nonautoimmune tfh cells. To compare differences in Tfh cells due to ongoing SLE disease, spontaneous splenic Tfh (CD4+CXCR5+PD-1+) were cell sorted from a pre-enriched population of negatively isolated total CD4 cells by autoMACS. New zealand derived triple congenic lupus strain was compared with B6/J. RNA was immediately extracted with no culturing or treatment of cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE106455 | GEO | 2018/05/01

REPOSITORIES: GEO