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Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection

ABSTRACT: Acute respiratory tract viral infections (ARTI) cause significant morbidity and mortality. While CD8 T cells are fundamental to the host response, the transcriptional alterations underlying anti-viral mechanisms within these cells, and the links to clinical characteristics, remain unclear. The transcriptional circuitry in CD8 T cells from acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens. We used microarray analysis to profile sorted CD8 T cells from PBMCs of various influenza-like illness patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106475 | GEO | 2018/01/09

SECONDARY ACCESSION(S): PRJNA416941

REPOSITORIES: GEO

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