Dataset Information


Candida albicans_NSC319726 treated_vs._control transcriptome data

ABSTRACT: We investigated the antifungal mechanism of action (MOA) of compound NSC319726 against C. albicans SC5314. We used transcriptome analysis of wild type C. albicans treated or not with compound. Exponentially growing cells were treated for 60 min with 4 μg/ml of NSC319726. Overall design: Exponentially growing cells were treated for 60 min with 4 μg/ml of NSC319726. The total RNAs were extracted from treated and control cells, then used to synthesize cDNA for microarray assays with Agilent DesignID 037557 that contains 6101 genes in duplicate.

INSTRUMENT(S): Agilent-037557 C. albicans 12K (111122 Georgetown David on C Albicans) [ORF version]

SUBMITTER: Dongmei Li 

PROVIDER: GSE106486 | GEO | 2017-11-04



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Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity.

Sun Nuo N   Li Dongmei D   Zhang Yuhan Y   Killeen Kyle K   Groutas William W   Calderone Richard R  

Scientific reports 20171205 1

The lack of new antifungal compounds with unique mechanisms of action is a concern for therapeutic management of patients. To identify inhibitors against human pathogenic fungi, we screened ~3000 compounds provided by the Developmental Therapeutics Program of NIH/NCI against a panel of pathogenic fungi including Candida species, Aspergillus fumigatus, and Cryptococcus neoformans. NSC319726 (a thiosemicarbazone) had broad antifungal activity in the range of 0.1-2.0 µg/ml and was also inhibitory t  ...[more]

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