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High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

ABSTRACT: Genes repressed by DNA methylation can be derepressed by various compounds targeting DNA methyltransferases, histone deacetylases, etc. Here, we report a high throughput screen against a 308,251-member chemical library aiming to identify novel small molecules that derepress an EGFP reporter gene silenced by DNA methylation. RNA-seq was used to measure mRNA abundance in control and compound-treated cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106573 | GEO | 2018/03/12

REPOSITORIES: GEO

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High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

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