Dataset Information


Sorted Mouse Phagocytes RNAseq

ABSTRACT: RNAseq of murine CD11b+ CD103+ DCs and CD11b+ CX3CR1+ Mononuclear Phagocyes Overall design: Cells were sorted from the colonic lamina propria of CX3CR1-GFP/+ mice

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: Irina Leonardi 

PROVIDER: GSE106594 | GEO | 2018-01-15



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CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.

Leonardi Irina I   Li Xin X   Semon Alexa A   Li Dalin D   Doron Itai I   Putzel Gregory G   Bar Agnieszka A   Prieto Daniel D   Rescigno Maria M   McGovern Dermot P B DPB   Pla Jesus J   Iliev Iliyan D ID  

Science (New York, N.Y.) 20180101 6372

Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1+ mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1+ MNPs express antifungal receptors and activate antifungal respon  ...[more]

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