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Endogenous expression of CD83 in Foxp3+ T cells essentially contributes to differentiation and function of murine Foxp3+ effector regulatory T cells

ABSTRACT: Foxp3-positive regulatory T (Treg) cells are crucial players for the maintenance of immune homeostasis and keep immune responses in check. Upon activation, Treg are transferred into an effector state expressing transcripts essential for their suppressive activity, migration and survival. However, how different intrinsic and environmental factors control differentiation is still not completely understood. Here, we present for the first time data suggesting that Treg intrinsic expression of CD83 is essential for Treg differentiation upon activation. Interestingly, mice with Treg intrinsic CD83 deficiency are characterized by a pro-inflammatory phenotype. Furthermore, the loss of CD83 expression by Treg leads to the downregulation of Treg specific differentiation markers and the induction of an inflammatory profile. In addition, Treg specific conditional knockout mice showed aggravated autoimmunity and an impaired resolution of inflammation. Altogether, CD83 expression in Treg cells is an essential factor for the development and function of effector Treg cells upon activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE106598 | GEO | 2020/03/31

REPOSITORIES: GEO

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