Increased expression of Ankyrin repeat domain 1 (ANKRD1) associates with the resistance mechanism of osimertinib resistant non-small cell lung cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]
SUBMITTER: 
Akiko Takahashi
PROVIDER: GSE106765 | GEO | 2017-11-11
SECONDARY ACCESSION(S): PRJNA417935
REPOSITORIES: GEO
Dataset's files
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Publications
Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer.
Takahashi Akiko A Seike Masahiro M Chiba Mika M Takahashi Satoshi S Nakamichi Shinji S Matsumoto Masaru M Takeuchi Susumu S Minegishi Yuji Y Noro Rintaro R Kunugi Shinobu S Kubota Kaoru K Gemma Akihiko A
Scientific reports 20181005 1
Overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is critical in combating EGFR-mutant non-small cell lung cancer (NSCLC). We tried to construct a novel therapeutic strategy to conquer the resistance to second-and third-generation EGFR-TKIs in EGFR-positive NSCLC patients. We established afatinib- and osimertinib-resistant lung adenocarcinoma cell lines. Exome sequencing, cDNA array and miRNA microarray were performed using the established ...[more]
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