Transcriptomics,Genomics

Dataset Information

28

Short-term mastication after weaning upregulates GABAergic signalling and reduces dendritic spine in thalamus


ABSTRACT: Mastication enhances brain function and even mental health, but little is known molecular basis underlying the effects of chewing on neural development in early childhood we conducted experiment with rats fed a with soft or hard chow diet immediately after weaning and investigated the expression of genes were investigated after another 8 days of breeding. These results suggest that mastication in the early developing period upregulates GABAergic signaling genes, with a decrease of spine pruning in thalamus Overall design: As a preparatory phase of the breeding process, the rats were provided with powdered feed and water for two days to get, ad libitum. After that, the rats were divided into two groups in a manner such that the average weight is approximately the same between the groups. One group was fed a powdered feed (powder, P), other group was fed a solid feed (chow, C) for eight days.

INSTRUMENT(S): [Rat230_2] Affymetrix Rat Genome 230 2.0 Array

SUBMITTER: Tomiko Asakura 

PROVIDER: GSE106766 | GEO | 2018-03-06

REPOSITORIES: GEO

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Publications

Short-term mastication after weaning upregulates GABAergic signalling and reduces dendritic spine in thalamus.

Ogawa Mana M   Nagai Toshitada T   Saito Yoshikazu Y   Miyaguchi Hitonari H   Kumakura Kei K   Abe Keiko K   Asakura Tomiko T  

Biochemical and biophysical research communications 20180311 3


Mastication enhances brain function and mental health, but little is known about the molecular mechanisms underlying the effects of mastication on neural development in early childhood. Therefore, we analysed the gene expression in juvenile neural circuits in rats fed with a soft or chow diet immediately after weaning. We observed that the gene expression patterns in the thalamus varied depending on the diet. Furthermore, gene ontology analysis revealed that two terms were significantly enhanced  ...[more]

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