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Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

ABSTRACT: Purpose: To examine differential expression of genes in bovine macrophages under the influence of Toll-like receptor agonists. Goal: to study and understand the early phase of transcriptomic changes induced by Toll-like receptor in bovine macrophage cell line.

ORGANISM(S): Bos taurus

PROVIDER: GSE106843 | GEO | 2018/12/22

REPOSITORIES: GEO

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miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

Project description:Purpose: To examine differential expression of miRNA in bovine macrophages under the influence of Toll-like receptor agonists. Goal: to study and understand the miRNA regulation of early phase of transcriptomic changes induced by Toll-like receptor in bovine macrophage cell line.

2020-11-30 | GSE111162 | GEO

Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity in mice and primates

Project description:Comparison of gene expression profiles after infection with flaviviruses or tratment with toll-like receptor agonists

2019-05-29 | GSE131818 | GEO

Differential repression of TLR responses by PPARg and LXRs

Project description:Transrepression mediated by PPARg and LXRs agonists (GW7845 and GW3965) in primary macrophages stimulated with LPS or poly I:C. Thioglycollate-elicited macrophages were isolated from mice by peritoneal lavage 3 days following peritoneal injection of 2.5 ml 3% thioglycollate (DIFCO). Cells were plated in RPMI medium 1640 and 10% fetal bovine serum, washed after 5 h the medium was removed and cells were fed with fresh medium containing 0.5% fetal bovine serum. Cells were treated with LPS (Sigma) a concentration of 100 ng/ml or poly I:C (100 ng/ml) in the absence or presence of receptor-specific agonists for PPARγ (GW7845) or LXR (GW3965) at 1 µM concentrations. Results suggest signal-dependent nuclear receptors transrepression pathways. Reference: Molecular Determinants of Crosstalk between Nuclear Receptors and Toll-like Receptors Mediating Counter-regulation of Inflammatory Responses. Sumito Ogawa, Jean Lozach, Chris Benner, Gabriel Pascual, Rajendra K. Tangirala, Stefan Westin, Alexander Hoffmann, Shankar Subramaniam, Michael David, Michael G. Rosenfeld, and Christopher K. Glass. Cell, Vol 122, 707-721, 9 September 2005. Keywords: PPARg and LXRs agonists

2006-12-15 | GSE6346 | GEO

Expression profile of Human blood monocytes treated with bacterial lipids

Project description:Multiple studies have established associations between human gut bacteria and host physiology but determining the molecular mechanisms underlying these associations has been challenging1–3. Akkermansia muciniphila has been robustly associated with positive systemic effects on host metabolism, favorable outcomes to checkpoint blockade in cancer immunotherapy, and homeostatic immunity4–7. Here we report the identification of a lipid from A. muciniphila’s cell membrane that recapitulates the immunomodulatory activity of A. muciniphila in cell-based assays8. The isolated immunogen, a diacyl phosphatidylethanolamine with two branched chains (a15:0-i15:0 PE), was characterized through both spectroscopic analysis and chemical synthesis. The immunogenic activity of a15:0-i15:0 PE has a highly restricted structure-activity relationship, and its immune signaling requires an unexpected toll-like receptor 2/1 heterodimer9,10. Certain features of the phospholipid’s activity are noteworthy: it is significantly less potent than known natural and synthetic toll-like receptor 2 agonists; it preferentially induces some inflammatory cytokines but not others; and at low doses (1% of EC50) it resets activation thresholds and responses for immune signaling. Identifying both the molecule and an equipotent synthetic analog, its non-canonical toll-like receptor 2/1 signaling pathway, its immunomodulatory selectivity, and its low dose immunoregulatory effects provides a molecular mechanism for a model of A. muciniphila’s ability to set immunological tone and its varied roles in health and disease.

2022-07-10 | GSE199367 | GEO

Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

Project description:Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

| PRJNA418172 | ENA

miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

Project description:miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

| PRJNA436032 | ENA

Mus musculus

Project description:Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages

| PRJNA179268 | ENA

Expression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)

Project description:We used microarrays to detail the global programme of gene expression underlying Polo-like kinase inhibition with BI 2536 compound in mouse bone marrow-derived dendritic cells (BMDCs) stimulated with Toll-like receptor agonists LPS and poly(I:C).

2011-04-12 | GSE28520 | GEO

Transcriptional profiling of liver from mice treated with Toll-like receptor 5 agonists

Project description:Transcriptional profiling of liver from mice treated with Toll-like receptor 5 agonists

| PRJNA687421 | ENA

Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants

Project description:Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for different pathogen species and clones. Accordingly, Staphylococcus aureus clinical isolates differ substantially in their capacity to activate TLR2. Here we show that strong TLR2 stimulation depends on high-level production of phenol-soluble modulin (PSM) peptides in response to the global virulence activator Agr. PSMs are required for mobilizing lipoproteins, the TLR2 agonists, from the staphylococcal cytoplasmic membrane. Notably, the course of sepsis caused by PSM-deficient S. aureus is similar in wild-type and TLR2-deficient mice, but TLR2 is required for protection of mice against PSM-producing S. aureus. Thus, a crucial role of TLR2 depends on agonist release by bacterial surfactants. Modulation of this process may lead to new therapeutic strategies against Gram-positive infections.

2016-06-08 | PXD004283 | Pride

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