Transcriptomics,Genomics

Dataset Information

40

Herpesvirus-encoded microRNAs alter transcriptome of oral keratinocytes


ABSTRACT: We investigated the impact of on miR-H1 and miR-K12-3-3p- on host transcriptome focusing on gingival epithelial cells that are target sites for various HHV. Results: More than 1300 genes were altered by miR-H1 and miR-K12-3-3p expressing HOK. Overall design: Primary oral keratinocytes were transfected with miR-H1, miR-K12-3-3p or control mimic for 48 hours. Total RNA isolated from cells (n=4) was assessed for global transcriptome changes using Affymetrix Gene array .

INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]

SUBMITTER: Afsar Naqvi  

PROVIDER: GSE107005 | GEO | 2018-02-15

REPOSITORIES: GEO

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Publications

Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.

Naqvi Afsar R AR   Seal Alexandra A   Shango Jennifer J   Brambila Maria F MF   Martinez Gloria G   Chapa Gabriela G   Hasan Shirin S   Yadavalli Tejabhiram T   Jaishankar Dinesh D   Shukla Deepak D   Nares Salvador S  

Biochimica et biophysica acta. Gene regulatory mechanisms 20180315 5


MicroRNAs (miRNAs) are small, non-coding RNAs of ~18-25 nucleotides that have gained extensive attention as critical regulators in complex gene networks including immune cell lineage commitment, differentiation, maturation, and maintenance of immune homeostasis and function. Many viruses encode miRNAs that directly downregulate the expression of factors of the innate immune system, which includes proteins involved in promoting apoptosis and recruitment. In this study, we examined the expression  ...[more]

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