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Edited miR-378a-3p target genes

ABSTRACT: Wild-type (WT) miR-378a-3p or edited miR-378a-3p were expressed in SB2 KD-ADAR1 cells to identify the genes regulated by edited miR-378a-3p vs WT miR-378a-3p. PARVA was one of the genes identified to be regulated by edited miR-378a-3p. We demonstrate that this regulation of PARVA is lost in highly metastatic melanoma cells. Microarray analysis was used to evaluate the robustness and reproducibility of the method used to generate the ex vivo tumor tissue model and confirm its ability to recapitulate the essential features of the original tumor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107088 | GEO | 2018/02/22

REPOSITORIES: GEO

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Edited miR-378a-3p target genes

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