Regulation of gene expression upon inhibition of ROCK and MLCK in mammary epithelial cells

ABSTRACT: To understand how mechanical cues regulate cell metabolism, we compared early changes in gene expression in Ras-transformed MCF10AtK1 mammary epithelial cells grown in high cytoskeletal tension conditions (plastics) vs. cells grown in low cytoskeletal tension conditions (inhibition of the non-muscle myosin II regulatory kinases ROCK and MLCK with standard small-molecule inhibitors Y27632 and ML7, respectively). Keywords: Expression profiling by array

ORGANISM(S): Homo sapiens

PROVIDER: GSE107275 | GEO | 2019/02/05

REPOSITORIES: GEO