Transcriptomics

Dataset Information

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BHLHE40 modulates gene transcription in breast cancer cells exposed to hypoxia and low glucose


ABSTRACT: Knockdown of BHLHE40 expression significantly reduced primary tumor growth and spontaneous lung metastasis in an orthotopic xenograft model of human breast cancer. Gene expression analysis implicated a role of BHLHE40 in hypoxia-induced exosomic secretion of Heparin Binding Epidermal Growth Factor HBEGF, which promotes cell survival and invasion. BHLHE40 induces HBEGF transcription by blocking DNA binding of HDAC1 and HDAC2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107300 | GEO | 2018/10/30

REPOSITORIES: GEO

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