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Mechanical stretch induced transcriptomic profiles in cardiac myocytes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Human gammaherpesvirus 8 Rattus norvegicus JC polyomavirus Betapolyomavirus macacae Homo sapiens Human immunodeficiency virus 1 Human betaherpesvirus 5 Betapolyomavirus hominis Human alphaherpesvirus 1 Murid gammaherpesvirus 4 human gammaherpesvirus 4 Murid betaherpesvirus 1

PROVIDER: GSE107380 | GEO | 2018/03/17

REPOSITORIES: GEO

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Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

Project description:Mechanical forces are able to activate hypertrophic growth of cardiomyocytes in the overloaded myocardium. However, the transcriptional profiles triggered by mechanical stretch in cardiac myocytes are not fully understood. Here, we performed the first genome-wide time series study of gene expression changes in stretched cultured neonatal rat ventricular myocytes (NRVM)s, resulting in 205, 579, 737, 621, and 1542 differentially expressed (>2-fold, P < 0.05) genes in response to 1, 4, 12, 24, and 48 hours of cyclic mechanical stretch. We used Ingenuity Pathway Analysis to predict functional pathways and upstream regulators of differentially expressed genes in order to identify regulatory networks that may lead to mechanical stretch induced hypertrophic growth of cardiomyocytes. We also performed micro (miRNA) expression profiling of stretched NRVMs, and identified that a total of 8 and 87 miRNAs were significantly (P < 0.05) altered by 1-12 and 24-48 hours of mechanical stretch, respectively. Finally, through integration of miRNA and mRNA data, we predicted the miRNAs that regulate mRNAs potentially leading to the hypertrophic growth induced by mechanical stretch. These analyses predicted nuclear factor-like 2 (Nrf2) and interferon regulatory transcription factors as well as the let-7 family of miRNAs as playing roles in the regulation of stretch-regulated genes in cardiomyocytes.

| S-EPMC5856749 | biostudies-literature

Mechanical stretch induced transcriptomic profiles in cardiac myocytes II

Project description:The effect of cyclic mecanical stretch on cardiac gene expression was studied in neonatal rat ventricular myocytes (NRVMs).

2018-03-17 | GSE107551 | GEO

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

Project description:Mechanical stretch induced transcriptomic profiles in cardiac myocytes

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Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

Project description:The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

2018-03-17 | GSE107379 | GEO

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [1-12 hours]

Project description:The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

2018-03-17 | GSE107378 | GEO

Mechanical stretch induced transcriptomic profiles in cardiac myocytes II

Project description:Mechanical stretch induced transcriptomic profiles in cardiac myocytes II

| PRJNA420515 | ENA

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [1-12 hours]

Project description:Mechanical stretch induced transcriptomic profiles in cardiac myocytes [1-12 hours]

| PRJNA419925 | ENA

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

Project description:Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

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Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes

Project description:This SuperSeries is composed of the SubSeries listed below.