GATA-6 and NFkB Repress Caveolins Transcription in Bladder Smooth Muscle Hypertrophy

ABSTRACT: Microarray analysis of bladder RNA revealed down-regulation of CAV1, CAV2 and CAV3 gene transcription in both mice with obstruction-induced BSM hypertrophy, and in men with benign prostatic hyperplasia Knockout of NF-κB subunits or shRNA-mediated knockdown of GATA-6 in BSM increased CAV1, CAV2 and CAV3 transcription and promoter activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE107427 | GEO | 2018/12/17

REPOSITORIES: GEO