Genomics

Dataset Information

30

Mechanical stretch induced transcriptomic profiles in cardiac myocytes II


ABSTRACT: The effect of cyclic mecanical stretch on cardiac gene expression was studied in neonatal rat ventricular myocytes (NRVMs). Overall design: The effect of cyclic mecanical stretch on cardiac gene expression was studied in neonatal rat ventricular myocytes (NRVMs) 1, 4, and 12 hours after start of the stretching. There are 5 biological replicates at each timepoint.

INSTRUMENT(S): [Rat230_2] Affymetrix Rat Genome 230 2.0 Array

SUBMITTER: Jaana Rysae  

PROVIDER: GSE107551 | GEO | 2018-03-17

REPOSITORIES: GEO

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Publications

Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

Rysä Jaana J   Tokola Heikki H   Ruskoaho Heikki H  

Scientific reports 20180316 1


Mechanical forces are able to activate hypertrophic growth of cardiomyocytes in the overloaded myocardium. However, the transcriptional profiles triggered by mechanical stretch in cardiac myocytes are not fully understood. Here, we performed the first genome-wide time series study of gene expression changes in stretched cultured neonatal rat ventricular myocytes (NRVM)s, resulting in 205, 579, 737, 621, and 1542 differentially expressed (>2-fold, P < 0.05) genes in response to 1, 4, 12, 24, and  ...[more]

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