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Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE107660 | GEO | 2018/01/30

REPOSITORIES: GEO

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Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [hypothalamus]

Project description:Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the hypothalmus is strongly functionnaly connected to the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP, we hypothesized that a different neuronal functions at the level of hypothalamus between men and women could contribute to the gender difference in cardiovascular homeostasis. Females Spontaneous Hypertensive Rats (SHRs) clearly exhibit lower AP levels than their male counterparts at similar age and their hypothalamus is characterized by a specific gene expression profile. This gender dependence of AP level is less marked in the normotensive strain, Wistar Kyoto rats (WKY). In this study, we investigated the gender-dependent gene expression profile of the hypothalamus of WKY rats by using microarray technique.

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Gender differences of gene expression profiles in brain cardiovascular centers of SHRs

Project description:This SuperSeries is composed of the SubSeries listed below.

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Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [nucleus of solitarii tract]

Project description:Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP is strongly associated with the AP level, we hypothesized that a different neuronal functions at the level of the NTS between men and women could contribute to the gender difference in cardiovascular homeostasis. Females Spontaneous Hypertensive Rats (SHRs) clearly exhibit lower AP levels than their male counterparts at similar age and their NTS is characterized by a specific gene expression profile. This gender dependence of AP level is less marked in the normotensive strain, Wistar Kyoto rats (WKY). In this study, we investigated the gender-dependent gene expression profile of the NTS of WKY by using microarray technique.

2018-01-30 | GSE107658 | GEO

Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats

Project description:Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats

| PRJNA420981 | ENA

Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [hypothalamus]

Project description:Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [hypothalamus]

| PRJNA420986 | ENA

Gender differences of gene expression profiles in brain cardiovascular centers of SHRs [hypothalamus]

Project description:Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the hypothalmus is strongly functionnaly connected to the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP, we hypothesized that a different neuronal functions at the level of hypothalamus between men and women could contribute to the gender difference in cardiovascular homeostasis. Since females Spontaneous Hypertensive Rats (SHRs) clearly exhibit lower AP levels than their male counterparts at similar age, we investigated whether the hypothalamus of SHRs exhibit gender differences in gene expression by using microarray technique.

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Gender differences of gene expression profiles in brain cardiovascular centers of SHRs [nucleus of solitarii tract]

Project description:Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP, is strongly associated with the AP level, we hypothesized that a different neuronal functions at the level of NTS between men and women could contribute to the gender difference in cardiovascular homeostasis. Since females Spontaneous Hypertensive Rats (SHRs) clearly exhibit lower AP levels than their male counterparts at similar age, we investigated whether the NTS of SHRs exhibit gender differences in gene expression by using microarray technique.

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Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [nucleus of solitarii tract]

Project description:Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [nucleus of solitarii tract]

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Gender differences of gene expression profiles in brain cardiovascular centers of SHRs

Project description:Gender differences of gene expression profiles in brain cardiovascular centers of SHRs

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