Epigenome-wide association study of the whole blood DNA in men with congenital hypopituitarism disease

ABSTRACT: Congenital hypopituitarism (CH) is chracterized with one or more hormones secreted deficiency by the pituitary gland, which leads to metabolic disorders, amenorrhea and infertility of the patients; however, the involved molecular mechanisms has not yet fully elucidated. We examined genome-wide methylation levels of whole blood DNA in 12 CH patients and 12 age-matched controls using Illumina HumanMethylation450 array. Significantly different methylated loci were further validated in another 40 patients and 40 controls with quantitative bisulfite pyrosequencing method.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107737 | GEO | 2017/12/06

SECONDARY ACCESSION(S): PRJNA421224

REPOSITORIES: GEO