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Ex vivo P. falciparum from High vs Low transmission areas in east Africa

ABSTRACT: The aim of this study was to compare the transcriptomes of Plasmodium falciparum parasites sourced from high vs. low malaria transmission settings in east Africa in order to test the hypothesis that malaria parasites are locally adapted to their environment. In three separate experiments, parasites from ‘High’ vs. ‘Low’ transmission populations were taken from non-immune children and measured for gene expression levels by microarray against a reference genome. Two of these population comparisons were geographic in nature while the third was temporal, i.e., before and after a marked decline in malaria. This study is described in Rono MK, Nyonda MA, Simam JJ, Ngoi, JM et al. Nat Ecol Evol. PMID: .

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE108034 | GEO | 2017/12/18

SECONDARY ACCESSION(S): PRJNA422261

REPOSITORIES: GEO

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