Genomics

Dataset Information

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HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Mats Ljungman  

PROVIDER: GSE108151 | GEO | 2018-09-04

SECONDARY ACCESSION(S): GSE108150 GSE108149

REPOSITORIES: GEO

Dataset's files

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Publications


The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Levels of HNF1A and its target genes were found to be elevated in PCSCs and tumorspheres, and depletion of HNF1A resulted in growth inhibition, apoptosis, impaired tumorsphere formation, decreased PCSC ma  ...[more]