MiR-7977 transfer alter the transcriptome in bone marrow mesenchymal stem cells.

ABSTRACT: Acute myeloid leukemia (AML) cells release abundant exosomal miR-7977 that transfer into bone marrow (BM) mesenchymal stromal cells (MSCs). We have shown that exosomal miR-7977 was highly released from AML cells and was transferred into BM MSCs. It has been well known that a microRNA has multiple targets. In fact, miRDB predicted 633 targets. Based on these findings, control and miR-7977mimic were transferred into BM MSCs. Subsequently, alteration of transcriptome was analyzed to gain insight into the role of miR-7977 in bone marrow micro environment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108186 | GEO | 2019/03/18

REPOSITORIES: GEO