Ontology highlight
ABSTRACT:
INSTRUMENT(S): Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
SUBMITTER: Ganna Kalayda
PROVIDER: GSE108214 | GEO | 2018-04-17
REPOSITORIES: GEO
International journal of molecular sciences 20180307 3
The major obstacle in the clinical use of the antitumor drug cisplatin is inherent and acquired resistance. Typically, cisplatin resistance is not restricted to a single mechanism demanding for a systems pharmacology approach to understand a whole cell's reaction to the drug. In this study, the cellular transcriptome of untreated and cisplatin-treated A549 non-small cell lung cancer cells and their cisplatin-resistant sub-line A549rCDDP2000 was screened with a whole genome array for relevant gen ...[more]