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Omics score: 35

Key players of cisplatin resistance: towards a systems pharmacology approach

ABSTRACT: The cellular transcriptome of untreated and cisplatin-treated A549 non-small cell lung cancer cells and their cisplatin-resistant sub-line A549rCDDP2000 was screened with a whole genome array for gene candidates relevant for cisplatin resistance. Overall design: Sensitive and resistant non-small cell lung cancer cells were treated with 11 or 34 µM cisplatin or with the drug-free medium. Total RNA was isolated and analysed.

INSTRUMENT(S): Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)

SUBMITTER: Ganna Kalayda

PROVIDER: GSE108214 | GEO | 2018-04-17

REPOSITORIES: GEO

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Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach.

Sarin Navin N Engel Florian F Rothweiler Florian F Cinatl Jindrich J Michaelis Martin M Frötschl Roland R Fröhlich Holger H Kalayda Ganna V GV

International journal of molecular sciences 20180307 3

The major obstacle in the clinical use of the antitumor drug cisplatin is inherent and acquired resistance. Typically, cisplatin resistance is not restricted to a single mechanism demanding for a systems pharmacology approach to understand a whole cell's reaction to the drug. In this study, the cellular transcriptome of untreated and cisplatin-treated A549 non-small cell lung cancer cells and their cisplatin-resistant sub-line A549rCDDP2000 was screened with a whole genome array for relevant gen ...[more]

PMID: 29518977

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