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Investigation of gene expression changes after mindfulness awareness program or health education program

ABSTRACT: Research shows that mindfulness practice can alter the expression of genes associated with energy metabolism, telomere maintenance, inflammatory and stress response. The aim of this study was to determine if mindfulness awareness practice (MAP) or health education program (HEP) might reverse cognitive impairment and/or prevent further cognitive decline in 60 subjects (aged 60-90). We investigated the gene expression changes in subject with mild cognitive impairment randomized to either group after 9 months. We used Affymetrix GeneChip Human Genome U133 Plus 2.0 array to determine the differential gene expression between Pre- and Post-treatment samples from MAP and HEP group.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108215 | GEO | 2017/12/19

SECONDARY ACCESSION(S): PRJNA422866

REPOSITORIES: GEO

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Project description:Interventions: The intervention is a 9- week online mindfulness program called MindOnLine, which comprises three main components: (1) an educational component to increase participants’ knowledge about the science and practice of mindfulness and how it can benefit them in everyday life; (2) a formal mindfulness meditation practice to improve awareness and emotion regulation; and (3) an informal practice to teach participants how to bring mindfulness to daily activities. Mindfulness education will be delivered using videos and associated video scripts. A new theme is introduced each week with a new meditation practice, which participants will be encouraged to practise every day. Themes include: introduction, reducing stress, relating to emotions, self-compassion, communicating mindfully, living mindfully, reducing worry, reducing worries mindfully and maintaining mindfulness. Each video is approximately 5-10 minutes in length. At the end of each week, participants will receive an email with a link to the video introducing the theme for the upcoming week. The script for the videos will be available for downloading and printing in a pdf format so that participants can keep a copy for later reference. At the end of each video, participants will be reminded by email to continue with their daily meditation practice (formal practice), and given specific informal practice during their daily activities. Examples of informal practice include: Week 1 – This weeks, notice times you are aware; time you are fully engaged with what you are doing or giving your full attention to someone. And notice times you are not paying attention to the moment you are in; when you are distracted. See if you can notice the difference between these two modes of being.”; Week 2 – notice Primary outcome(s): Fear of cancer recurrence is the primary outcome of the study. The 42-item Fear of Cancer Recurrence Inventory (FCRI) is a multidimensional FCR scale intended for use with all cancer patients. Items were developed on the basis of a cognitive–behavioural formulation of FCR (range:0- 168)13. The FCRI consists of seven domains: triggers, severity, psychological distress, functional impairment, reassurance, insight and coping strategies (range:0-36). It has shown high internal consistency, good construct and criterion validity in adults with different cancer types. [9-weeks.] Study Design: Purpose: Educational / counselling / training; Allocation: Randomised controlled trial

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Investigation of gene expression changes after mindfulness awareness program or health education program

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