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Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity

ABSTRACT: The effect of T372E-EZH2 and Wt-EZH2 overexpression on gene expression in TOV112D cells. We found in this study that Protein Kinase A phosphorylates T372-EZH2 and wanted to determine the gene expression changes brought upon this phosphorylation. We made a point mutation (T372E) that mimicked phospho T372-EZH2. The objective was to observe transcriptional changes in TOV112D cells in response to ectopic expression of Wt-EZH2 and T372E-EZH2 point mutation in TOV112D cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108418 | GEO | 2018/06/05

REPOSITORIES: GEO

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