The role of CHD7 in human central nervous system development (ChIP-Seq)

ABSTRACT: CHARGE syndrome is a congenital disorder caused by mutations in Chromodomain Helicase DNA-binding domain 7 (CHD7) gene. We generated a cell line carrying HA-tag knock-in into the human CHD7 locus, mediated by CRISPR-Cas9 system. We then performed ChIP against HA antibody using the validated knock-in cells and subsequent high-throughput sequencing analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108506 | GEO | 2018/03/28

REPOSITORIES: GEO