Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of the Transcriptome Profile of four Tissue Specific MSCs: Significance and Therapeutic Implications

ABSTRACT: Performing global gene expression profiling for different types of (Mesenchymal stem cells) MSCs can provide important information that might help in understanding the biology and ontogeny of MSCs. Additionally, it might help in the understanding of the propensity and capacity of MSCs from a particular source to differentiate toward a particular lineage or adopt a certain fate. We used microarrays to detail the global gene expression profiling for different types of MSCs including bone marrow (BM), Adipose Tissue (AT), Umbilical cord (UC) and placenta(PL). The MSCs transcriptome profile was additionally compared to the transcriptome profile of dermal fibroblasts.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108511 | GEO | 2018/06/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data of paired human neonatal thymus MSCs vs bone MSCs

Project description:Neonatal thymus MSCs and bone derived MSCs have differential abilities to stimulate angiogenesis and invade extracellular matrix. We utilized microarray to identify differentially expressed genes between these two types of MSCs and analyzed this information in the context of the phenotypic differences between these two cell types.

2019-12-25 | GSE142563 | GEO

Differentially expressed (DE) genes analysis in synovial fluid mesenchymal stem cells (SF-MSCs), SF-MSC derived iPSCs and iPSC derived MSCs (iPSC-MSCs)

Project description:We report the application of next-generation sequencing (NGS) to analysis the gene expression profile among three different cells:SF-MSCs, iPSCs and iPSC-MSCs. Our results shown that iPSC-MSCs were more similar to SF-MSCs than iPSCs.

2018-10-04 | GSE120800 | GEO

Gene expression profile of modified MSCs

Project description:Gene expression profile of modified MSCs

| PRJNA762072 | ENA

Comparison of mesenchymal stem/stromal cells (MSCs) between human iPS-derived MSC and human primary cultured MSCs

Project description:To characterize and compare XF-iMSC (XenoFree-induced Mesenchymal stem/stromal cells) and various types of MSCs (Adipose-, Bone marrow-, Unbilical cord-derived), we performed a transcriptome analysis of these MSCs

2022-06-22 | GSE206172 | GEO

methylation profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear.We have found that the gene expression profile of psoriatic dermal MSCs was distinct different from normal MSCs. We proposed to investigate the DNA methylation profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the DNA methylation profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42634 | biostudies-arrayexpress

single cell multiome for MSCs

Project description:we used single-cell multiome analysis to profile the transcriptome and epigenome of MSCs from four healthy donors.

2023-11-09 | GSE228669 | GEO

RNA sequence of ISL1-MSCs and Ctrl-MSCs

Project description:RNA sequence of ISL1-MSCs and Ctrl-MSCs

| PRJNA421939 | ENA

methylation profile of dermal MSCs derived from psoriasis patients and normal control

2012-11-30 | GSE42634 | GEO

Improved Efficacy of MSCs stably expressing CXCR4 and IL-10 in a xenogeneic Graft versus Host Disease Mouse Model

Project description:Previous clinical trials have shown that mesenchymal stromal cells (MSCs) can modulate graft versus host disease (GvHD) after allogeneic hematopoietic transplantation, although with variable efficacy. To improve the anti-GvHD effect of these cells, adipose tissue derived-human MSCs (Ad-MSCs) were transduced with a lentiviral vector conferring stable expression of CXCR4, a molecule involved in cell migration to inflamed sites, and IL-10, a cytokine with potent anti-inflammatory properties. In vitro experiments showed that the expression of these molecules in Ad-MSCs (named CXCR4-IL10-MSCs) efficiently enhanced their migration towards SDF‐1α and also improved their immunomodulatory properties compared to unmodified Ad‐MSCs (WT‐MSCs). Moreover, using a humanized GvHD mouse model, CXCR4-IL10-MSCs showed improved therapeutic effects, which were confirmed by histopathologic analysis in the target organs. Additionally, compared to WT-MSCs, CXCR4-IL10-MSCs induced a more marked reduction in the number of pro-inflammatory Th1 and Th17 cells, a higher polarization towards an anti-inflammatory T cell profile (CD3+-IL10+ cells), and increased the number of regulatory T and B cells. Our in vitro and in vivo studies strongly suggest that CXCR4-IL10-MSCs should constitute an important new generation of MSCs for the treatment of GvHD in patients transplanted with allogeneic hematopoietic grafts.

2023-01-25 | GSE223390 | GEO

Comparison of the Transcriptome Profile of four Tissue Specific MSCs: Significance and Therapeutic Implications

Project description:Comparison of the Transcriptome Profile of four Tissue Specific MSCs: Significance and Therapeutic Implications

| PRJNA427526 | ENA