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Identification of the molecular signature of distinctive breast cancer associated fibroblasts (CAFs)

ABSTRACT: Cancer associated fibroblasts (CAFs) are highly heterogeneous and different subsets of CAFs may exhibit distinct functions, To identify the molecular signature of distinctive CAFs , we compared mRNA expression profiles of CAFs isolated from tumors in sensitive patients and resistant ones before neo-adjuvant chemotherapy. Compared the CAFs from sensitive samples, those from refractory samples exhibited a distinctive signature.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108565 | GEO | 2018/01/08

SECONDARY ACCESSION(S): PRJNA427700

REPOSITORIES: GEO

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