Transcriptomic analysis of hiPSC-derived neurons, pre-treated or not with KU-55933 compound (ATMi), after camptothecin (CPT) exposure and release.

ABSTRACT: The goal of the analysis was to determine the effect of Top1ccs blocking, elicited by CPT, on global transcription in hiPSC-derived neurons, in which ATM was catalytically inhibited or not with KU-55933. Particular attention was focused on the correlation between CPT-modulated genes and gene length and on the potential involvement of ATM in this phenomenon.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108605 | GEO | 2019/06/10

REPOSITORIES: GEO