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Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature

ABSTRACT: The purpose of this study was to analyze the genomic signatures and profiles of skin from ichthyosis (various subtypes) vs. healthy patients. The analysis strategy was to study differentially expressed genes common to the ichthyosis shared phenotype, as well as individual ichthyosis subtypes, and compare and contrast to the genomic profiles of atopic dermatitis and psoriasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108640 | GEO | 2018/10/10

REPOSITORIES: GEO

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Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.

Project description: Not available

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Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature

Project description:Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature

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Transcriptomic Analysis of the Major Orphan Ichthyosis Subtypes Reveals Shared Immune and Barrier Signatures

Project description:In this study we performed the first global RNA-seq analysis in 54 ichthyosis patients (7 Netherton syndrome/NS, 13 epidermolytic ichthyosis/EI, 16 lamellar ichthyosis/LI, 18 congenital ichthyosiform erythroderma/CIE) and 40 healthy controls. Differentially expressed genes (DEGs) were defined based on fold changes/FCH>2 and false discovery rate/FDR<0.05 criteria. We found robust and significant Th22/Th17 skewing in all subtypes (e.g. IL-17A/C/F, S100A7/8/9/12; p<0.001) with modest changes in Th2 pathway, primarily in NS, and Th1 skewing in CIE.

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