Hair growth is induced by blockade of macrophage-derived oncostatin M and JAK-STAT5 signaling in hair follicle stem cells.

ABSTRACT: We also show that OSM is sufficient for maintaining quiescence of hair follicle stem cells (HFSCs), and OSMRβ-JAK-STAT5 signaling is necessary for maintaining the resting phase of the hair cycle (telogen). Using single-cell RNA sequencing, we identify the source of OSM to be a distinct subset of TREM2+ macrophages that predominate during early telogen. Moreover, inhibition of macrophages during telogen by genetic ablation, neutralizing antibodies and small-molecule inhibitors was sufficient to induce anagen.

ORGANISM(S): Mus musculus

PROVIDER: GSE108709 | GEO | 2019/04/09

REPOSITORIES: GEO