Targeting the vulnerability of RB tumor suppressor loss in triple negative breast cancer

ABSTRACT: Approximately 30% of TNBCs exhibit loss of function of the RB tumor suppressor. The study used RNA sequencing to profile RB-proficient and RB-deficient TNBC cases that were defined based on immunostaining for RB and p16ink4a. The analyses revealed that RB-deficient TNBC cases express elevated levels of DNA replication and mitotic genes that could serve as the basis for increased sensitivity to drugs targeting cell cycle checkpoints.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108757 | GEO | 2018/01/05

SECONDARY ACCESSION(S): PRJNA428502

REPOSITORIES: GEO