TIP60 represses activation of endogenous retroviral elements

ABSTRACT: We found that the loss of TIP60 de-represses retrotransposon elements genome-wide, which in turn activate the cellular response to pathogens mediated by STING, culminating in an induction of Interferon Regulatory Factor 7 (IRF7) and associated inflammatory response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108834 | GEO | 2019/12/01

REPOSITORIES: GEO