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A unique pair of microarray datasets for microRNA profiling: data with careful design (Dataset A)

ABSTRACT: We set out to demonstrate the logistic feasibility of careful study design in microarray studies and the level of scientific benefits it can provide, in comparison with post-hoc data adjustment such as normalization, for preventing confounding handling effects and improving the accuracy and reproducibility of disease-relevant biomarker detection. Towards this end, we conducted a study of microRNA expression using endometroid endometrial cancer tumors (n=96) and serous ovarian cancer tumors (n=96) that were all primary, untreated, and collected in 2000-2012 at Memorial Sloan Kettering Cancer Center. The same set of tumor tissue samples were profiled twice using the Agilent microRNA microarrays with different study designs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108838 | GEO | 2018/01/08

SECONDARY ACCESSION(S): PRJNA428875

REPOSITORIES: GEO

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A unique pair of microarray datasets for microRNA profiling: data without careful design (Dataset B)

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