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Gamma-irradiation induced T-cell lymphomas (miRNA study)

ABSTRACT: This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias

ORGANISM(S): Mus musculus

PROVIDER: GSE10891 | GEO | 2008/06/26

SECONDARY ACCESSION(S): PRJNA108893

REPOSITORIES: GEO

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Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas

2008-06-26 | GSE10859 | GEO

Gamma-irradiation induced T-cell lymphomas (miRNA study)

Project description:This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

2010-05-26 | E-GEOD-10891 | biostudies-arrayexpress

Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas

2008-06-26 | GSE10858 | GEO

Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas

Project description:This set of data contains the expression levels of cDNAs in T-cell lymphoblastci lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

2010-05-26 | E-GEOD-10859 | biostudies-arrayexpress

Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas

Project description:This analysis compares the signal of DNA from T-cell lymphoblastic lymphomas induced by gamma-irradiation versus normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

2010-05-26 | E-GEOD-10858 | biostudies-arrayexpress

T-cell lymphoblastic lymphomas induced by gamma-irradiation

Project description:This SuperSeries is composed of the following subset Series: GSE10858: Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas GSE10859: Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas GSE10891: Gamma-irradiation induced T-cell lymphomas (miRNA study) Keywords: SuperSeries Refer to individual Series

2010-05-26 | E-GEOD-10861 | biostudies-arrayexpress

B cell Lymphomas present Immunoglobulin Neoantigens

Project description:Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chromatography and tandem mass spectrometry (LC-MS/MS) to define antigens presented by follicular lymphomas (FL), chronic lymphocytic leukemias (CLL), diffuse large B cell lymphoma (DLBCL) and mantle cell lymphomas (MCL). We found presentation of the clonal immunoglobulin molecule, including neoantigens by both class I and class II MHC, though more commonly in class II MHC. To determine whether B cell activation could promote presentation of immunoglobulin neoantigens, we used a toll-like receptor 9 (TLR9) agonists to upregulate expression of MHC-II. This resulted in enhanced class II MHC presentation of the immunoglobulin variable region including neoantigens. These findings demonstrate that immunoglobulin neoantigens are presented across most subtypes of B cell lymphomas. Activation of lymphoma cells to upregulate antigen presentation boosts presentation of immunoglobulin neoantigens and represents a strategy for augmenting lymphoma immunotherapies.

2019-01-07 | PXD010808 | Pride

Expression data from mouse T-cell lymphomas

Project description:Transgenic expression of TLX1 induces T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1 tumors compared with different genetic models T acute lymphoblastic lymphoma.

2010-10-19 | GSE19499 | GEO

Homo sapiens

Project description:gene expression analyses of pediatric lymphoblastic lymphomas and leukemias

| PRJNA140703 | ENA

Expression data from mouse T-cell lymphomas

Project description:Transgenic expression of key transcritpion factors inducing T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1transgenic /RUNX1 heterozygous tumors compared with different genetic models T acute lymphoblastic lymphoma.

2011-11-08 | GSE33549 | GEO

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