Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Saccharomyces cerevisiae)
SUBMITTER: Nicholas R Guydosh
PROVIDER: GSE108942 | GEO | 2018-08-30
REPOSITORIES: GEO
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Molecular cell 20180823 5
The recycling of ribosomal subunits after translation termination is critical for efficient gene expression. Tma64 (eIF2D), Tma20 (MCT-1), and Tma22 (DENR) function as 40S recycling factors in vitro, but it is unknown whether they perform this function in vivo. Ribosome profiling of tma deletion strains revealed 80S ribosomes queued behind the stop codon, consistent with a block in 40S recycling. We found that unrecycled ribosomes could reinitiate translation at AUG codons in the 3' UTR, as evid ...[more]