Allopregnanolone alters the gene expression profile of human glioblastoma cells

ABSTRACT: Glioblastomas (GBM) are one of the most frequent and aggressive brain tumors. In these malignancies, progesterone (P4) promotes proliferation, migration, and invasion. The P4 metabolite allopregnanolone (3α-THP) similarly promotes cell proliferation in the U87 human GBM cell line. Here, we evaluated global changes in gene expression of U87 cells treated with 3α-THP, P4, and the 5α-reductase inhibitor, finasteride (F).

ORGANISM(S): Homo sapiens

PROVIDER: GSE108998 | GEO | 2018/02/11

REPOSITORIES: GEO