Genomics

Dataset Information

4

Transcriptional analysis of resting or inflamed murine Macrophages with Immune complex stimulation


ABSTRACT: We wished to investigate differential effects of stimulation with immune complex on colonic macrophages taken from mice which were either healthy or had DSS induced colitis. Overall design: 4 samples from resting mice, 8 from mice which have DSS induced inflammation. After extraction of macrophages from the colon half the samples were treated with OVA and half with OIC.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: John Robert Ferdinand 

PROVIDER: GSE109040 | GEO | 2019-03-18

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE109040_CountTable.csv.gz Csv
GSE109040_DE_IC_from_DSS.csv.gz Csv
GSE109040_Normalized_counts.csv.gz Csv
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Publications


Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding affinity of the antibody receptor it encodes, FcγRIIA, for immunoglobulin G (IgG). Here, we aimed to understand the mechanisms whereby changes in FcγRIIA affinity would affect inflammation in an IgA-dominated organ. We found a profound induction of anti-commensal IgG and a  ...[more]

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