Expression data from purified mouse CD4+ T cells

ABSTRACT: T cells are the main responding arm of the immune system to allografts. One mechanism that may be encouraging tolerance to allografts is T regulatory cells, a CD4+ T cell phenotype that displays antigen-directed immune suppression. T regulatory cells are reduced after allografting in the graft draining lymph node compared to the syngeneic graft draining lymph node, and miRNAs may be responsible for this decrease in suppressive cells. We used microarrays to detail what miRNAs are dysregulated after allografting in purified CD4+ T cells to identify what miRNAs are hindering the expansion of pro-tolerogenic T regulatory cells.

ORGANISM(S): synthetic construct Mus musculus

PROVIDER: GSE109160 | GEO | 2018/01/13

SECONDARY ACCESSION(S): PRJNA429803

REPOSITORIES: GEO