Transcriptomics,Genomics

Dataset Information

31

RNA seq_PDX2_SHP099


ABSTRACT: RNA seq data of PDX2 treated with vehicle of SHP099 --> to check senescence and SASP gene expression signatures Overall design: PDX2 KRAS mut NSCLC tumors implanted in 12 different mice, 5 treated with vehicle, 7 with SHP099, during 19 days.

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Sara Mainardi 

PROVIDER: GSE109270 | GEO | 2018-04-01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE109270_readcounts_PDX2_vehicle_SHP099.xlsx Xlsx
Items per page:
1 - 1 of 1
altmetric image

Publications


RAS mutations are frequent in human cancer, especially in pancreatic, colorectal and non-small-cell lung cancers (NSCLCs)1-3. Inhibition of the RAS oncoproteins has proven difficult4, and attempts to target downstream effectors5-7 have been hampered by the activation of compensatory resistance mechanisms8. It is also well established that KRAS-mutant tumors are insensitive to inhibition of upstream growth factor receptor signaling. Thus, epidermal growth factor receptor antibody therapy is only  ...[more]

Similar Datasets

2018-01-01 | S-EPMC6711172 | BioStudies
2020-01-01 | S-EPMC7278897 | BioStudies
2012-01-01 | E-GEOD-27389 | ArrayExpress
2016-01-01 | S-EPMC5065110 | BioStudies
2012-01-01 | GSE27389 | GEO
2019-01-01 | S-EPMC6697189 | BioStudies
2016-01-01 | S-EPMC4966329 | BioStudies
2014-01-01 | S-EPMC4278592 | BioStudies
2019-01-01 | S-EPMC6859675 | BioStudies
1000-01-01 | S-EPMC5386578 | BioStudies