Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3

ABSTRACT: Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss.

ORGANISM(S): Mus musculus

PROVIDER: GSE109279 | GEO | 2018/01/18

SECONDARY ACCESSION(S): PRJNA430334

REPOSITORIES: GEO