Dataset Information


Effect of NORAD shRNA on A549 cells treated with TGF-beta

ABSTRACT: We evaluated the effect of NORAD (also known as LINC00657 or LOC647979) shRNA on TGF-beta induced changes in the gene expression in A549 cells by RNA-seq. Overall design: mRNA expression was determined in a lung adenocarcinoma cancer cell line A549 infected with NORAD shRNA-expressing lentiviral vector and treated with TGF-beta.

INSTRUMENT(S): Ion Torrent Proton (Homo sapiens)

SUBMITTER: Daizo Koinuma  

PROVIDER: GSE109296 | GEO | 2018-04-26


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Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype.

Kawasaki Natsumi N   Miwa Toshiki T   Hokari Satoshi S   Sakurai Tsubasa T   Ohmori Kazuho K   Miyauchi Kensuke K   Miyazono Kohei K   Koinuma Daizo D  

Cancer science 20180529 7

Long noncoding RNAs are involved in a variety of cellular functions. In particular, an increasing number of studies have revealed the functions of long noncoding RNA in various cancers; however, their precise roles and mechanisms of action remain to be elucidated. NORAD, a cytoplasmic long noncoding RNA, is upregulated by irradiation and functions as a potential oncogenic factor by binding and inhibiting Pumilio proteins (PUM1/PUM2). Here, we show that NORAD upregulates transforming growth facto  ...[more]

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