Dataset Information


Next generation sequencing based transcriptome comparison between wild-type Drosophila and an Alzheimer's disease model

ABSTRACT: Gene expression profiling of wild-type (WT) fruit flies and transgenic flies that express human amyloid precursor protein was performed to investigate how Aβ42 affects the transcriptome of Drosophila. Overall design: Head tissues from 3-, 10- and 20-day-old male WT and Alzheimer’s disease (AD) Drosophila model were collected for RNA isolation and high-throughput sequencing.

INSTRUMENT(S): HiSeq X Ten (Drosophila melanogaster)

ORGANISM(S): Drosophila Melanogaster

SUBMITTER: Xianda Hu  

PROVIDER: GSE109489 | GEO | 2020-06-02


Dataset's files

Action DRS
GSE109489_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image


Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging.

Wang Min M   Peng I-Feng IF   Li Simin S   Hu Xianda X  

Aging 20200106 1

Alzheimer's disease (AD) is an age-related neurodegenerative disease with unknown mechanism that is characterized by the aggregation of abnormal proteins and dysfunction of immune responses. In this study, an integrative approach employing <i>in silico</i> analysis and wet-lab experiment was conducted to estimate the degrees of innate immune system relevant gene expression, neurotoxic Aβ<sub>42</sub> generation and neuronal apoptosis in normal <i>Drosophila melanogaster</i> and a transgenic mode  ...[more]

Similar Datasets

| S-EPMC8564532 | BioStudies
| S-EPMC7612234 | BioStudies
| S-EPMC8752909 | BioStudies
| S-EPMC8016515 | BioStudies
| S-EPMC8720757 | BioStudies
| S-EPMC8573146 | BioStudies
2012-01-01 | S-EPMC5561919 | BioStudies
| S-EPMC9243174 | BioStudies
| S-EPMC8603492 | BioStudies
| S-EPMC3108982 | BioStudies