Dataset Information


Next generation sequencing based transcriptome comparison between wild-type Drosophila and an Alzheimer's disease model

ABSTRACT: Gene expression profiling of wild-type (WT) fruit flies and transgenic flies that express human amyloid precursor protein was performed to investigate how Aβ42 affects the transcriptome of Drosophila. Overall design: Head tissues from 3-, 10- and 20-day-old male WT and Alzheimer’s disease (AD) Drosophila model were collected for RNA isolation and high-throughput sequencing.

INSTRUMENT(S): HiSeq X Ten (Drosophila melanogaster)

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Xianda Hu  

PROVIDER: GSE109489 | GEO | 2020-06-02


Dataset's files

Action DRS
GSE109489_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image


Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging.

Wang Min M   Peng I-Feng IF   Li Simin S   Hu Xianda X  

Aging 20200106 1

Alzheimer's disease (AD) is an age-related neurodegenerative disease with unknown mechanism that is characterized by the aggregation of abnormal proteins and dysfunction of immune responses. In this study, an integrative approach employing <i>in silico</i> analysis and wet-lab experiment was conducted to estimate the degrees of innate immune system relevant gene expression, neurotoxic Aβ<sub>42</sub> generation and neuronal apoptosis in normal <i>Drosophila melanogaster</i> and a transgenic mode  ...[more]

Similar Datasets

2012-01-01 | S-EPMC5561919 | BioStudies
2015-01-01 | S-EPMC4683859 | BioStudies
2011-01-01 | S-EPMC3108982 | BioStudies
2018-01-01 | S-EPMC6083707 | BioStudies
2020-12-08 | PXD015443 | Pride
2015-01-01 | S-EPMC4625140 | BioStudies
2018-01-01 | S-EPMC6454565 | BioStudies
2020-04-01 | GSE118599 | GEO
2017-01-01 | S-EPMC5357677 | BioStudies
2019-01-01 | S-EPMC6429702 | BioStudies