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RNA-seq analysis of HuH-7, NCI-H1299 and HEK-293T cells

ABSTRACT: The diversity and complexity of the cancer transcriptome hold the potential to yield tumor-specific transcripts (TSTs) in cancer. We report a novel LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. LIN28B-TST initiates from a de novo alternative transcription initiation site. We found that LIN28B-TST was expressed in HuH-7 HCC cells and NCI-H1299 lung cancer cells, while wild-type LIN28B (LIN28B-WT) was expressed in HEK-293T human embryo kidney cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109528 | GEO | 2018/01/24

REPOSITORIES: GEO

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