Alzheimer's disease DNA (hydroxy) methylome in the brain: OXT methylation as a preclinical marker.

ABSTRACT: The present study investigated the DNA methylome and hydroxymethylome, as well as unmodified cytosine in relation to Alzheimer’s disease (AD). We identified epigenetic differences between AD patients and age-matched controls in the middle temporal gyrus, in genomic regions associated with genes such as OXT, ACSL1, RHBDF2, C3, and MIR9-3HG. Interestingly, we found that OXT methylation in the blood of aged, non-demented individuals is also associated with conversion to AD dementia. The current GEO records concerns the middle temporal gyrus (ox)BS-processed Illumina 450K dataset of this study.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109627 | GEO | 2019/12/09

REPOSITORIES: GEO