Genomics

Dataset Information

0

Expression data of Familial adenomatous polyposis (FAP) organoids


ABSTRACT: FAP is an autosomal-dominant inherited disease caused by germline mutations in the APC gene 1. Two major FAP phenotypes, CFAP and AFAP, can be distinguished based on polyp numbers and age of onset. CFAP is characterized by the presence of hundreds to thousands of polyps. About half of these patients develop adenomas by age 15, and 95% develop adenomas by age 35. AFAP patients exhibit a milder phenotype than CFAP patients; AFAP is characterized by fewer polyps, later adenoma onset, and lower CRC risk. We used microarrays to analyze the expression profiles of organoids established from three CFAP and two AFAP patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109812 | GEO | 2019/12/31

REPOSITORIES: GEO

Similar Datasets

2019-12-31 | GSE109813 | GEO
2021-08-19 | GSE136044 | GEO
2018-02-27 | GSE111156 | GEO
2021-09-01 | GSE156172 | GEO
| PRJNA561096 | ENA
| PRJNA432077 | ENA
| PRJNA432078 | ENA
| S-EPMC2840009 | biostudies-other
2018-02-16 | GSE94919 | GEO
| 2239967 | ecrin-mdr-crc